Polypharmacy is an ever-increasing concern for today’s mental health administrators. The amount of psychiatric polypharmacy has been increasing each year. The main focus of polypharmacy awareness has been related to both clinical concerns – such as patient safety and more effective, evidence-based prescribing – and costs. This whitepaper raises awareness of inappropriate polypharmacy, the use of polypharmacy that goes against good medical evidence and practice. It also provides possible solutions for mental health care providers to manage it.